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Research Project by Gifted Gabber Alumni - Sinchana Keshav
Project's Result
Published in the Journal of Student Research: Access the Full Paper Here
Gifted Gabber Research Program
This impactful research was conducted during the 2022 Research Program at Gifted Gabber, under the guidance of Research Professor Rajagopal Appavu and Mentor Coach Jo.
Research Summary
Metastasis, the spread of cancer from its primary site to other parts of the body, remains a critical challenge in cancer treatment. Sinchana Keshav’s research delves into the mechanisms driving metastasis in abdominal organs, offering an in-depth analysis of its progression and the impact of various treatment modalities.
This study investigates the biological pathways and cellular behaviors that enable cancer cells to invade, survive, and colonize distant organs such as the liver, pancreas, and gastrointestinal tract. Key insights include the roles of epithelial-to-mesenchymal transition (EMT), angiogenesis, and immune system evasion in facilitating metastasis.
Furthermore, the research evaluates the efficacy of current treatment options, including surgical intervention, chemotherapy, targeted therapy, and immunotherapy, in managing metastatic abdominal cancers. Findings highlight the need for personalized treatment plans that address the unique molecular profiles of each patient’s cancer.
By uncovering the complexities of metastatic processes and assessing the potential of emerging therapies, Sinchana Keshav’s work contributes to the development of more effective strategies for combating advanced-stage cancers. Her research underscores the importance of early detection, innovative treatments, and a multidisciplinary approach to improve outcomes for patients battling metastatic diseases.